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The perform of SIK1 in tumorigenesis. SIK1 is really a tumor suppressor gene, which performs a very important regulatory purpose in GNAS, KRAS mutation and LKB1 deletion mediated tumors. SIK1 inhibits CREB mediated transcription and influences cancer mobile proliferation, metabolic reprogramming and inflammatory microenvironment. SIK1 could also ad… Read More